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Updated: Aug 21, 2026

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
Published on: December 14, 2017
[Searching genetic risk factors for sporadic Parkinson's disease]
1Division of Functional Genomics, Osaka University Graduate School of Medicine.
Abstract:
Multiple genetic and environmental factors are thought to cause idiopathic Parkinson's disease (PD). To identify the genetic factors, we are carrying case-control association studies by genome-wide MS (microsatellite) markers and SNP (single nucleotide polymorphism) markers on the candidate genes, and sib-pair analysis. We investigated 27,000 MS markers and found 8% of them were significantly associated with PD in the first screening. In the candidate gene approach, of 267 SNPs on 122 candidate genes, 22 SNPs on 16 genes showed significant p-values (less than 0.05) by chi-square statistics. The further analysis is necessary to identify causative genes for PD.
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