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Cutaneous leishmaniasis: The prospects for a killed vaccine

C L Greenblatt1

  • 1Hebrew University, Hodossah Medical School, Jerusalem, POB 1172, Code 91010, Jerusalem, Israel.

Parasitology Today (Personal Ed.)
|February 1, 1988
PubMed

Insights

Cutaneous leishmaniasis (CL) vaccines show promise due to available models and human study experience. Current plans involve field trials of killed vaccines, building on established leishmanization practices.

Area of Science:

  • Parasitology
  • Vaccinology
  • Tropical Medicine

Background:

  • Cutaneous leishmaniasis (CL) is a chronic protozoal disease with ongoing vaccine development.
  • Existing experimental models and human study data provide a foundation for vaccine research.

Purpose of the Study:

  • To review the experience with attenuated and killed vaccines for cutaneous leishmaniasis.
  • To discuss the implications of this experience for current vaccine trial strategies.

Main Methods:

  • Review of existing research and clinical experience with CL vaccines.
  • Discussion of established practices like 'leishmanization' in Iran.

Main Results:

  • Cutaneous leishmaniasis presents a strong candidate for successful vaccine development.
  • Extensive experience with various vaccine types informs future trials.

Conclusions:

  • Current World Health Organization - Tropical Disease Research (WHO-TDR) plans focus on field trials of killed CL vaccines.
  • These trials will incorporate virulent challenge, similar to historical leishmanization methods.

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