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Schistosome surface antigens: developmental expression and immunological function.

A J Simpson1

  • 1Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

Parasitology Today (Personal Ed.)
|February 1, 1990
PubMed
Summary
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Not all surface antigens on parasitic schistosomes are protective targets. Developmental expression may determine the immunological function of these surface antigens, challenging long-held assumptions about immune responses.

Area of Science:

  • Parasitology
  • Immunology
  • Molecular Biology

Background:

  • Antigens on parasitic organisms are traditionally considered key targets of protective immunity.
  • This view is being challenged by emerging evidence regarding schistosome antigens.

Purpose of the Study:

  • To investigate the immunological function of schistosome surface antigens.
  • To explore the role of developmental expression in determining antigen function.

Main Methods:

  • Analysis of schistosome surface antigen expression.
  • Immunological assays to assess immune responses.

Main Results:

  • Not all protective schistosome antigens are located on the surface.
  • Not all surface antigens elicit protective immune responses.

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Conclusions:

  • The immunological function of schistosome surface antigens is complex.
  • Developmental expression is a critical factor influencing the immune targeting of schistosome antigens.