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Updated: Jun 25, 2026
Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors
Published on: November 25, 2010
Alphavirus expression systems: applications to mosquito vector studies
S Higgs1, A M Powers, K E Olson
1Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
Abstract:
In this review, Steve Higgs, Ann Powers and Ken Olson describe how alphavirus expression systems, based on infectious cDNA clones of Sindbis virus, constitute a novel RNA virus delivery system suitable for the efficient expression of heterologous gene products or RNA sequences in mosquito cells or adult mosquitoes. The technique permits ready assessment of molecular genetic-based methods of intracellular interference to infection and provides a powerful new tool for molecular biological studies in arthropods.
