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Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients
07:25

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients

Published on: July 16, 2020

Fosfomycin therapy for multiresistant Pseudomonas aeruginosa in cystic fibrosis

A Mirakhur1, M J Gallagher, M J Ledson

  • 1Regional Adult CF Unit, The Cardiothoracic Centre, Liverpool, UK.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|October 7, 2004
PubMed
Abstract

Insights

Intravenous Fosfomycin effectively treated pulmonary exacerbations in cystic fibrosis (CF) patients with Pseudomonas aeruginosa infections. This antibiotic demonstrated good tolerability and clinical improvement in CF patients with multidrug-resistant bacteria.

Area of Science:

  • Medical Microbiology
  • Pharmacology
  • Pulmonology

Background:

  • Pseudomonas aeruginosa demonstrates increasing antibiotic resistance in cystic fibrosis (CF) patients.
  • Fosfomycin offers a unique mechanism of action against P. aeruginosa and potential protection against aminoglycoside toxicity.
  • Limited clinical data exists for intravenous (IV) Fosfomycin, particularly in the UK.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of IV Fosfomycin in treating pulmonary exacerbations in adult CF patients.
  • To assess the impact of Fosfomycin treatment on respiratory function and renal parameters.
  • To document side effects associated with IV Fosfomycin use in this population.

Main Methods:

  • A prospective study involving 15 adult CF patients with P. aeruginosa colonization.
  • Treatment comprised IV Fosfomycin in combination with other antibiotics for 30 pulmonary exacerbations.
  • Sputum cultures, spirometry, renal function tests, and symptom assessments were performed pre- and post-treatment.

Main Results:

  • Clinical resolution of chest exacerbations was observed in most patients (mean FEV1% predicted increased from 41.1 to 49.4, P<0.001).
  • One patient experienced nausea, leading to treatment withdrawal.
  • A minor, statistically significant increase in plasma urea was noted, remaining within normal limits; plasma creatinine was unchanged.

Conclusions:

  • Intravenous Fosfomycin is well-tolerated in adult CF patients.
  • Fosfomycin is a potentially valuable treatment option for CF patients colonized with multidrug-resistant P. aeruginosa.

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