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Tissue Doppler-derived myocardial acceleration for evaluation of left ventricular diastolic function
Ikuo Hashimoto1, Aarti Hejmadi Bhat, Xiaokui Li
1Clinical Care Center for Congenital Heart Disease, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.
Journal of the American College of Cardiology
|October 7, 2004
Summary
Peak myocardial acceleration (pACC) during isovolumic relaxation is a sensitive, preload-independent marker for left ventricular diastolic function. PACC during LV filling also correlates with left atrial pressure.
Area of Science:
- Cardiology
- Echocardiography
- Diastology
Background:
- Clinical evaluation of diastolic function requires simple, practical indices.
- Current methods for assessing left ventricular diastolic function are complex.
Purpose of the Study:
- To evaluate peak myocardial acceleration (pACC) as an index for left ventricular (LV) diastolic function.
- To assess pACC during isovolumic relaxation and LV filling.
Main Methods:
- Tissue Doppler imaging was used to obtain mitral valve annular velocity in eight sheep.
- Peak myocardial acceleration (pACC) was derived during isovolumic relaxation and LV filling.
- Hemodynamic status was altered, and pACC was compared with LV pressure changes (-dP/dt(min)) and time constant (tau).
Main Results:
- Septal pACC during isovolumic relaxation correlated well with -dP/dt(min) (r = -0.80) and tau (r = -0.87).
- Septal pACC during LV filling correlated well with mean left atrial pressure (LAP) (r = 0.81).
- LV lateral wall pACC showed a weak correlation with mean LAP.
Conclusions:
- Peak myocardial acceleration (pACC) during isovolumic relaxation is a sensitive, preload-independent marker for LV diastolic function.
- PACC during LV filling is a useful indicator of mean LAP.