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The Australian Mohs database: periocular squamous intraepidermal carcinoma
Raman Malhotra1, Craig L James, Dinesh Selva
1Oculoplastic & Orbital Unit, Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia.
Ophthalmology
|October 7, 2004
Summary
Mohs micrographic surgery (MMS) for periocular squamous intraepithelial carcinoma (IEC) in Australia showed low recurrence rates. This study highlights significant subclinical tumor extension, emphasizing the need for precise surgical techniques.
Area of Science:
- Dermatology
- Oncology
- Surgical Pathology
Background:
- Periocular squamous intraepithelial carcinoma (IEC) is a common skin malignancy.
- Mohs micrographic surgery (MMS) is a specialized technique for skin cancer removal.
- Data on MMS outcomes for periocular IEC in Australia were previously limited.
Purpose of the Study:
- To report the findings and outcomes of periocular IEC treated with MMS.
- To evaluate recurrence rates and clinical features of primary and recurrent IEC.
- To assess subclinical tumor extension in periocular IEC cases.
Main Methods:
- Prospective, noncomparative, multicenter, interventional case series.
- 53 patients with periocular IEC underwent MMS between 1993 and 1999.
- Outcomes included recurrence, tumor site, size, prior recurrence, and defect size.
Main Results:
- Most IECs were on the lower eyelid (51%) or medial canthus (32%).
- Significant subclinical tumor extension was observed in 25% of cases.
- Overall recurrence rate was 8.3% after a mean follow-up of 77.4 months (5.3% for primary, 11.8% for recurrent IEC).
Conclusions:
- Periocular IEC exhibits significant subclinical tumor extension.
- Clinical features of primary and recurrent IEC showed no significant differences.
- Low recurrence rates with MMS underscore its efficacy for periocular IEC management.