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Related Experiment Videos

Vocal fold augmentation with calcium hydroxylapatite.

Peter C Belafsky1, Gregory N Postma

  • 1Department of Otolaryngology, UC Davis Medical Center, Sacramento, CA 95817, USA. pcb@san.rr.com

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 7, 2004
PubMed
Summary

Calcium hydroxylapatite (CaHA) injections show promise for vocal fold augmentation, improving patient outcomes without adverse reactions. Further studies are needed to confirm long-term safety and efficacy in treating voice disorders.

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Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Voice disorders impact over 3% of the population, with vocal fold atrophy common in aging.
  • Current injection augmentation options for vocal folds lack ideal safety, efficacy, and durability.
  • Presbylaryngia and vocal fold paralysis are significant causes of glottal insufficiency.

Purpose of the Study:

  • To evaluate the preliminary experience with calcium hydroxylapatite (CaHA) for vocal fold augmentation.
  • To assess the safety, functional outcomes, and histological response to CaHA injections.
  • To determine the potential of CaHA as a viable injectable filler for glottal insufficiency.

Main Methods:

  • Prospective evaluation of 23 patients (39 vocal folds) receiving CaHA injections between 2002 and 2003.

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  • Data collection on indications, injection technique, functional outcomes, and complications.
  • Histological examination of a donated larynx post-CaHA augmentation.

    • Main Results:

    • No adverse reactions were reported in any patients.
    • All patients reported significant improvement in voice function (P < 0.001).
    • Histology confirmed intact CaHA spherules with minimal inflammatory response and no implant rejection.

    Conclusions:

    • Preliminary results suggest CaHA is a promising agent for vocal fold augmentation.
    • CaHA injections led to functional improvements and demonstrated good biocompatibility.
    • Long-term safety and efficacy of CaHA for vocal fold augmentation require further investigation.