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Updated: Aug 21, 2026

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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
An analogue of adenine that forms an "A:T" base pair of comparable stability to G:C
James Booth1, W Jon Cummins, Tom Brown
1School of Chemistry, University of Southampton, Highfield, Southampton, UK SO17 1BJ.
Abstract:
The heterocyclic base 7-aminopropargyl-7-deaza-2,6-diaminopurine (D) has been incorporated into oligodeoxynucleotides. D:T has similar thermodynamic stability to G:C and is a stable analogue of A:T.
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