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Gianotti-Crosti syndrome caused by acute hepatitis B virus genotype D infection
Kojiro Michitaka1, Norio Horiike, Yan Chen
1Endoscopy Center, Ehime University School of Medicine, Shigenobucho, Onsen-gun, Ehime 791-0295.
Abstract:
A 12-year-old girl with Gianotti-Crosti syndrome caused by hepatitis B virus (HBV) infection was admitted due to eruption on her extremities. Laboratory findings revealed elevation of transaminase, positivity for HB surface antigen (HBsAg), and an IgM type anti-HB core. The eruption and level of transaminase improved, and HBsAg became negative within 2 months of onset. Analysis of the virus revealed it to be genotype D with a genomic length of 3,182 bases and the HBsAg serotype was ayw3, which is very rare in Japan. The possible relationship between Gianotti-Crosti syndrome and HBV genotype D infection is discussed.
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