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Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease
Shogo Kitahata1, Kojiro Michitaka2, Miyuki Kinebuchi3
1Gastroenterology Center, Ehime Prefectural Central Hospital, Japan.
Abstract:
No reports of renal cancer in patients with Wilson's disease (WD) exist. We herein report a 37-year-old Japanese man diagnosed with WD who had been treated with d-penicillamine 9 years prior. Hepatocellular carcinoma had been diagnosed at 36 years old and treated with radiofrequency ablation therapy. One year later, renal cancer and recurrent hepatocellular carcinoma had developed. The hepatocellular carcinoma was treated after renal cancer surgical resection of a clear-cell-type renal cell carcinoma, with iron, rather than copper, deposited on the renal cancer cells. This patient harbored a novel mutation, p. Leu1395Terfs in ATP7B.
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