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Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Large duodenal somatostatinoma in the third portion associated with severe glucose intolerance
Ryosuke Kimura1, Yoshinari Hayashi, Toyo Takeuchi
1Department of Internal Medicine, Kariya General Hospital, 5-15 Sumiyoshi-cho Kariya, Aichi 448-8505.
Abstract:
A 51-year-old man was admitted with hyperglycemia and a duodenal tumor. Although his glycemic control was poor, basal C-peptide levels were not suppressed. Further examination revealed a mass measuring 7.8 cm in diameter in the third portion of the duodenum. Duodenectomy revealed a slow-growing sessile tumor located near Treitz's ligament. The immunohistochemical profile of sections of the specimen revealed the presence of somatostatin. The patient's serum somatostatin was elevated to 300 pg/ml preoperatively, but was reduced to 10 pg/ml postoperatively. Glycemic control also normalized after the operation.
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