Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rosette formation in osteosarcoma.

Nirmala A Jambhekar1, Tanuja M Shet, Lolly Das

  • 1Department of Pathology, Tata Memorial Hospital, Parel, Mumbai-400012, India. najambhekar@rediffmail.com

Indian Journal of Pathology & Microbiology
|October 9, 2004
PubMed
Summary

Rosette formation in osteosarcoma is rare and linked to poor prognosis. Documenting this finding is crucial for accurate diagnosis and understanding its impact on patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concordance of conventional two-tier HER2 classification versus three-tier classification (including HER2-low status) in invasive breast carcinoma: a retrospective real-world analysis.

Journal of clinical pathology·2026
Same author

Understanding Low-Grade Fibromatosis-Like Metaplastic Breast Carcinoma, a Tertiary Care Center Experience: Case Series and Review of Literature.

International journal of surgical pathology·2025
Same author

Biomarker Concordance of Invasive Breast Carcinoma on Re-Evaluation: A Comprehensive Retrospective Real-World Analysis of Paired Samples.

JCO global oncology·2025
Same author

Microglandular adenosis associated with invasive breast carcinoma: Tertiary care oncology centre experience of an under-recognized entity.

Annals of diagnostic pathology·2025
Same author

Validation of uPath HER2 dual-colour dual in-situ hybridisation image analysis tool for HER2/neu testing in breast cancer.

Journal of clinical pathology·2025
Same author

Primary central nervous system lymphoma: Comprehension of cell-of-origin subtypes.

Indian journal of pathology & microbiology·2023

Area of Science:

  • Orthopedic Oncology
  • Skeletal Pathology
  • Tumor Histopathology

Background:

  • Osteosarcoma is a primary bone malignancy with varied histological presentations.
  • Rosette formation is a recently identified, rare variant of osteosarcoma.
  • This pattern is often associated with a poorer prognosis in bone tumors.

Observation:

  • Two cases of rosette-forming osteosarcoma were analyzed.
  • One case showed a poor response to chemotherapy, while the other achieved total necrosis.
  • Histopathological awareness is needed to differentiate from other bone tumors like PNET/Ewing sarcoma.

Findings:

  • Rosette formation in osteosarcoma presents a diagnostic challenge.
  • The prognostic significance of rosettes in osteosarcoma requires further elucidation.
  • Chemotherapy response can vary in rosette-forming osteosarcoma.

Implications:

  • Pathologists must recognize rosette formation to prevent misdiagnosis of osteosarcoma.
  • Documenting rosettes aids in differential diagnosis and understanding prognostic factors.
  • Further research is needed to clarify the definitive prognostic implications of this osteosarcoma variant.

Related Experiment Videos