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Related Experiment Videos

Paradoxical embolism in a preterm infant.

Luca Filippi1, Ludovica Palermo, Marco Pezzati

  • 1Neonatal Intensive Care Unit, Department of Critical Care Medicine, University Careggi Hospital, viale Morgagni, 85 I1-50134 Florence, Italy. filippi.luca@virgilio.it

Developmental Medicine and Child Neurology
|October 12, 2004
PubMed
Summary

Paradoxical embolism, a condition where blood clots travel from veins to arteries, is identified as a cause of stroke in newborn infants. This finding suggests it may be a more common complication than previously recognized in neonates.

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Area of Science:

  • Neonatal Neurology
  • Pediatric Cardiology
  • Vascular Medicine

Background:

  • Cryptogenic stroke in neonates remains a diagnostic challenge.
  • Cerebral paradoxical embolism is an underrecognized cause of stroke in this population.

Observation:

  • A preterm male infant presented with respiratory distress and encephalopathy at 17 days of life.
  • Deep venous thrombosis and a patent foramen ovale were identified.
  • Clinical progression and neuroradiological findings confirmed paradoxical embolism.

Findings:

  • This case describes cerebral paradoxical embolism as a cause of cryptogenic stroke in a newborn.
  • The incidence of patent foramen ovale and deep venous thrombosis in neonates suggests this complication may be more frequent than previously thought.

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Implications:

  • Highlights the importance of considering paradoxical embolism in neonatal stroke evaluation.
  • Suggests increased vigilance for deep venous thrombosis and patent foramen ovale in at-risk neonates.
  • May lead to revised diagnostic and management strategies for neonatal stroke.