Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The budding yeast spindle pole body: structure, duplication, and function.

Sue L Jaspersen1, Mark Winey

  • 1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA. jasperse@colorado.edu

Annual Review of Cell and Developmental Biology
|October 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapy-Associated Polyposis in Pediatric Cancer Survivors.

Pediatric blood & cancer·2026
Same author

A ternary complex of MIPs in the A-tubule of basal bodies and axonemes depends on RIB22 and the EF-hand domain of RIB72A in <i>Tetrahymena</i> cilia.

Molecular biology of the cell·2025
Same author

Plasticity of the mitotic spindle in response to karyotype variation.

Current biology : CB·2024
Same author

Translational control of MPS1 links protein synthesis with the initiation of cell division and spindle pole body duplication in Saccharomyces cerevisiae.

Genetics·2024
Same author

Spindle checkpoint activation by fungal orthologs of the S. cerevisiae Mps1 kinase.

PloS one·2024
Same author

Seizures in trisomy 18: Prevalence, description, and treatment.

American journal of medical genetics. Part A·2023
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

Microtubule organizing centers (MTOCs) are vital for cell functions. This review details the budding yeast spindle pole body (SPB), a key MTOC, and its role in understanding other MTOCs like animal cell centrosomes.

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Microtubule organizing centers (MTOCs) are essential for diverse cellular processes, including cell division and motility.
  • While MTOC structures vary across organisms, their fundamental role in microtubule nucleation and assembly principles are conserved.

Purpose of the Study:

  • To provide a comprehensive review of the budding yeast spindle pole body (SPB), a well-characterized MTOC.
  • To explore the structure, composition, duplication, regulation, and functions of the yeast SPB.
  • To highlight how SPB research informs the study of other MTOCs, particularly animal cell centrosomes.

Main Methods:

  • Literature review of studies on microtubule organizing centers (MTOCs).
  • Focus on research concerning the budding yeast spindle pole body (SPB).

Related Experiment Videos

  • Comparative analysis of MTOCs across different eukaryotic organisms.

    • Main Results:

    • The budding yeast SPB serves as a model MTOC with conserved components and assembly principles.
    • Detailed understanding of SPB structure, protein composition, duplication, and regulation.
    • Insights from SPB studies are transferable to understanding centrosome biology.

    Conclusions:

    • The yeast SPB is a critical model for understanding MTOC function and evolution.
    • Conserved mechanisms in MTOC assembly and regulation are evident across eukaryotes.
    • Research on the SPB significantly advances knowledge of centrosomes and other MTOCs.