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Related Experiment Videos

Adaptors for clathrin coats: structure and function.

David J Owen1, Brett M Collins, Philip R Evans

  • 1Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2XY, UK. djo30@cam.ac.uk

Annual Review of Cell and Developmental Biology
|October 12, 2004
PubMed
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Clathrin adaptors link clathrin scaffolds to cell membranes, forming dynamic networks essential for clathrin-coated vesicle (CCV) formation. Understanding adaptor structure reveals mechanisms driving CCV biogenesis.

Area of Science:

  • Cell biology
  • Molecular and structural biology
  • Membrane trafficking

Background:

  • Clathrin-coated vesicles (CCVs) mediate protein transport in secretory and endocytic pathways.
  • Clathrin adaptors link the clathrin scaffold to cellular membranes.

Purpose of the Study:

  • To review the structure of clathrin adaptors.
  • To elucidate how adaptor structure informs the mechanism of CCV formation.

Main Methods:

  • Structural analysis of clathrin adaptors.
  • Review of literature on adaptor protein interactions and CCV biogenesis.

Main Results:

  • Clathrin adaptors bind clathrin, transmembrane proteins, and/or phospholipids.
  • Adaptors form multi-component networks through moderate-strength interactions.

Related Experiment Videos

  • These networks regulate CCV genesis timing and location.

    • Conclusions:

    • The structure of clathrin adaptors is critical for their function in CCV formation.
    • Adaptor interactions create dynamic, regulatable networks driving vesicle biogenesis.