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Related Experiment Videos

Laminin functions in tissue morphogenesis.

Jeffrey H Miner1, Peter D Yurchenco

  • 1Renal Division, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. minerj@wustl.edu

Annual Review of Cell and Developmental Biology
|October 12, 2004
PubMed
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Genetics reveals how basement membrane laminins guide tissue development from embryo to adulthood. These proteins are crucial for cell polarity, tissue organization, and preventing cell death during morphogenesis.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Genetics

Background:

  • Basement membrane laminins are crucial extracellular matrix proteins.
  • Laminins play vital roles in tissue development and maintenance.

Purpose of the Study:

  • To review the contributions of laminins to tissue morphogenesis.
  • To explore the genetic basis of laminin function in development.

Main Methods:

  • Genetic studies in invertebrates and vertebrates.
  • Analysis of laminin subunit functions.
  • Review of existing literature on laminin structure and function.

Main Results:

  • Laminin subunits significantly impact tissue morphogenesis from embryonic implantation through postnatal development.

Related Experiment Videos

  • Laminins induce and maintain cell polarity.
  • Laminins establish tissue compartment barriers and organize cells into tissues.
  • Laminins protect cells from anoikis (detachment-induced cell death).

    • Conclusions:

    • Genetic insights have elucidated key functions of basement membrane laminins in tissue morphogenesis.
    • Laminins are essential regulators of cell polarity, tissue organization, and cell survival during development.