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Estrogen receptor alpha and beta expression in uterine leiomyomas from premenopausal women
Artur J Jakimiuk1, Michal Bogusiewicz, Rafal Tarkowski
1Second Department of Gynecology, University School of Medicine, Lublin, Poland. yakimiuk@yahoo.com
Objective:
To measure messenger RNA levels of estrogen receptor (ER) alpha and beta in uterine leiomyomas, normal myometrium, and endometrium.
Design:
Prospective study.
Setting:
University hospital.
Patient(S):
Seventeen premenopausal women who underwent surgery due to symptomatic uterine leiomyomas.
Intervention(S):
None.
Main Outcome Measure(S):
Quantitative RT-PCR was used for evaluation of ERalpha and ERbeta expression. Results were normalized to total cellular DNA.
Result(S):
Expression of ERalpha and ERbeta did not differ between leiomyomas and myometrium; however, in both tissues, expression of ERalpha was significantly higher than that of ERbeta. Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium. In leiomyomas and endometrium, correlations between expression of ERalpha and ERbeta were found.
Conclusion(S):
Uterine leiomyomas, myometrium, and endometrium display distinct patterns of ER expression.
