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Updated: Aug 21, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
New approaches in immunotherapy: allergen vaccination with immunostimulatory DNA
Peter Socrates Creticos1, Yi-Hsing Chen, John T Schroeder
1Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, 5501 Hopkins Bayview Circle, Room 2B, 71, Baltimore, MD 21224, USA. pcretic@jhmi.edu
Abstract:
Despite its success, conventional immunotherapy is saddled with a number of encumbrances. An allergenic vaccine that could reduce allergenicity, maintain immunogenicity, and be given in a few doses would have important therapeutic implications, as millions of patients with poorly controlled allergic rhinitis and asthma would be candidates for such a form of immunomodulation. This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen.
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