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Related Experiment Videos

Intracranial inflammatory pseudotumor.

J E Sitton1, J C Harkin, M A Gerber

  • 1Department of Pathology, Tulane University School of Medicine, New Orleans, Louisiana 70112.

Clinical Neuropathology
|January 1, 1992
PubMed
Summary
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An intracranial mass initially diagnosed as a meningioma was found to be an inflammatory pseudotumor. This reactive lesion, composed of plasma cells and lymphocytes, highlights the importance of considering pseudotumors in differential diagnoses.

Area of Science:

  • Neuropathology
  • Neurosurgery
  • Oncology

Background:

  • Intracranial masses often present diagnostic challenges.
  • Meningiomas are common intracranial tumors, but other lesions can mimic their appearance.
  • Accurate diagnosis is crucial for appropriate patient management.

Purpose of the Study:

  • To report a case where an intracranial mass was misdiagnosed as a meningioma.
  • To describe the histopathological and immunohistochemical findings of an inflammatory pseudotumor.
  • To emphasize the inclusion of inflammatory pseudotumor in the differential diagnosis of suspected meningiomas.

Main Methods:

  • Clinical and radiological evaluation including computed tomography and angiography.
  • Histopathological examination of the resected intracranial mass.

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  • Immunohistochemical analysis to determine cell population characteristics.

    • Main Results:

    • The intracranial mass, suspected to be a meningioma, was histopathologically identified as an inflammatory pseudotumor.
    • The lesion consisted of mature plasma cells and lymphocytes with germinal centers.
    • Immunohistochemistry confirmed a polyclonal cell population, indicative of a reactive process, not a neoplasm.

    Conclusions:

    • Inflammatory pseudotumor can mimic meningioma clinically and radiologically.
    • Histopathological and immunohistochemical analyses are essential for differentiating reactive lesions from neoplasms.
    • Consideration of inflammatory pseudotumor in the differential diagnosis of intracranial masses is recommended.