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[Morphological brain changes in senile depressions. A morphometric computed tomographic study].

C Wurthmann1, B Bogerts, B Höft

  • 1Psychiatrische Klinik, Universität Düsseldorf.

Deutsche Medizinische Wochenschrift (1946)
|March 20, 1992
PubMed
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Computed tomography (CT) revealed enlarged brain ventricles and sulci in patients with senile depression, suggesting pre-existing structural changes rather than progressive atrophy. This highlights the importance of considering cerebral morphology in geriatric psychiatric conditions.

Area of Science:

  • Neurology
  • Geriatric Psychiatry
  • Radiology

Background:

  • Senile depression is a significant geriatric psychiatric condition.
  • Cerebral morphological changes may be associated with senile depression.
  • Computed tomography (CT) is a valuable tool for visualizing brain structures.

Purpose of the Study:

  • To investigate whether CT can detect morphological brain changes in patients with senile depression.
  • To compare cerebrovascular spaces in senile depression patients versus a healthy control group.

Main Methods:

  • Planimetric measurement of inner and outer cerebrovascular spaces using CT.
  • Inclusion of 34 patients with senile depression and a control group (n=43).
  • Statistical comparison of ventricular and sulcal sizes between groups.

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Main Results:

  • Significant enlargement of lateral ventricles (P < 0.05) in senile depression patients.
  • Significant enlargement of occipital sulci (P < 0.05) and lateral sulci (P < 0.01) compared to controls.
  • No correlation found between brain changes and depression duration or severity.

Conclusions:

  • Findings suggest pre-existing cerebral structural changes in senile depression, not a progressive atrophy.
  • Cerebral morphological alterations warrant greater attention in senile psychiatric conditions.
  • CT-detected brain changes may provide insights beyond psychosocial factors in geriatric depression.