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Steroid-induced ocular hypertension in normal cattle
Rosana Gerometta1, Steven M Podos, Oscar A Candia
1Department of Ophthalmology, Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes, Argentina.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|October 13, 2004
Summary
Cows develop elevated intraocular pressure (IOP) after topical corticosteroid use, creating a reliable animal model for steroid-induced glaucoma research. This ocular hypertensive response resolves slowly after treatment cessation.
Area of Science:
- Ophthalmology
- Veterinary Medicine
- Pharmacology
Background:
- Topical corticosteroids are widely used but can induce elevated intraocular pressure (IOP).
- Understanding the mechanisms of steroid-induced ocular hypertension is crucial for managing glaucoma.
- A reliable animal model is needed to study this phenomenon.
Purpose of the Study:
- To investigate if bovine eyes develop elevated intraocular pressure (IOP) in response to topical corticosteroid administration.
- To establish a dependable animal model for steroid-induced elevation of IOP.
Main Methods:
- 12 cows received topical prednisolone acetate in one eye for 49 days.
- Intraocular pressure (IOP) was measured using Perkins applanation tonometry.
- IOP was monitored for 50 days post-treatment cessation.
Main Results:
- 100% of treated bovine eyes showed increased IOP after 3 weeks of corticosteroid use.
- Peak IOP differences reached 15 mm Hg between treated and control eyes.
- Elevated IOP persisted for 3 weeks after treatment discontinuation.
Conclusions:
- Bovine eyes exhibit a consistent, robust steroid-induced ocular hypertensive response.
- The IOP elevation gradually subsides after corticosteroid treatment stops.
- This bovine model offers opportunities to study steroid-induced glaucoma mechanisms relevant to human primary open-angle glaucoma.