Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive posterior cortical dysfunction: a clinicopathologic series.

J A Renner1, J M Burns, C E Hou

  • 1Department of Psychiatry, Washington University, St. Louis, MO, USA.

Neurology
|October 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease.

The journal of prevention of Alzheimer's disease·2024
Same author

Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease.

medRxiv : the preprint server for health sciences·2023
Same author

Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2023
Same author

Editorial: How Will Aducanumab Approval Impact AD Research?

The journal of prevention of Alzheimer's disease·2021
Same author

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.

Endocrine-related cancer·2021
Same author

Editorial: Is Now the Time for Combination Therapies for Alzheimer Disease?

The journal of prevention of Alzheimer's disease·2019
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Alzheimer's disease is the most common cause of progressive posterior cortical dysfunction (PPCD), a dementia characterized by visuospatial deficits. However, other neurodegenerative disorders can also cause PPCD.

Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Atypical presentations of neurodegenerative dementias include progressive posterior cortical dysfunction (PPCD), marked by visuospatial deficits.
  • The underlying neuropathology of PPCD is not well understood.

Observation:

  • A retrospective case series examined 27 individuals clinically diagnosed with PPCD.
  • Neuropathologic examination was performed on 21 participants.
  • Psychometric data from 65 individuals with mild Alzheimer type dementia (DAT) were used for comparison.

Findings:

  • Alzheimer's disease (AD) was the most frequent cause of PPCD (n=13).
  • Other causes included AD with other pathologies, dementia with Lewy bodies, corticobasal degeneration, and prion diseases.

Related Experiment Videos

  • Individuals with PPCD showed distinct psychometric profiles with greater visuospatial deficits compared to DAT.

    • Implications:

    • AD is a primary cause of PPCD, but non-Alzheimer dementias must also be considered in diagnosis.
    • Understanding PPCD neuropathology is crucial for accurate diagnosis and management of atypical dementias.
    • This study highlights the importance of considering diverse etiologies in PPCD.