Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homocysteine and cognitive function in elderly people.

Angeles Garcia1, Katherine Zanibbi

  • 1Department of Medicine, Queen's University, Kingston, Ont. garciaa@pccchealth.org

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
|October 13, 2004
PubMed
Summary

Dementia is a growing concern in the elderly population. This review explores the link between homocysteine, a byproduct of methionine metabolism, and cognitive decline, suggesting its role in dementia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Burnout among healthcare workers in Lebanon: a multicentred cross-sectional study.

BMJ public health·2026
Same author

Management of Post-Viral Postural Orthostatic Tachycardia Syndrome With Craniosacral Therapy.

Cureus·2023
Same author

Fear of Falling in Older Adults with Diabetes Mellitus: The IMIAS Study.

Canadian journal on aging = La revue canadienne du vieillissement·2018
Same author

A pilot investigation of an iOS-based app for toilet training children with autism spectrum disorder.

Autism : the international journal of research and practice·2017
Same author

Age related prefrontal compensatory mechanisms for inhibitory control in the antisaccade task.

NeuroImage·2017
Same author

Quantitative 3D Telomeric Imaging of Buccal Cells Reveals Alzheimer's Disease-Specific Signatures.

Journal of Alzheimer's disease : JAD·2017

Area of Science:

  • Gerontology
  • Neurology
  • Biochemistry

Background:

  • Dementia prevalence is rising significantly in the elderly, necessitating effective prevention and early detection strategies.
  • Established risk factors for dementia include age and education, with emerging research focusing on homocysteine.
  • Homocysteine, an amino acid derived from methionine metabolism, is linked to cognitive function and dementia.

Purpose of the Study:

  • To review the evidence associating elevated serum homocysteine levels with cognitive decline and dementia.
  • To explore potential mechanisms by which homocysteine impacts brain function and contributes to cognitive impairment.
  • To examine homocysteine metabolism and factors that disrupt its normal regulation.

Main Methods:

  • Literature review of studies investigating homocysteine levels and cognitive function.

Related Experiment Videos

  • Analysis of research on the biochemical pathways of homocysteine metabolism.
  • Examination of factors influencing homocysteine levels, including B vitamin status.

    • Main Results:

    • Evidence suggests a correlation between increased serum homocysteine and impaired cognitive function.
    • Homocysteine may exert neurotoxic effects, contributing to cognitive dysfunction and dementia.
    • Alterations in homocysteine metabolism, often linked to B vitamin deficiencies, are associated with cognitive decline.

    Conclusions:

    • Elevated homocysteine is a significant factor associated with cognitive decline and dementia in the elderly.
    • Understanding homocysteine metabolism and its relationship with B vitamins is crucial for dementia prevention and treatment.
    • Further research into homocysteine-lowering strategies may offer therapeutic benefits for cognitive health.