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Updated: Aug 21, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

[Effects of immunomodulating therapy on immune status and the disease course in patients with relapsing herpetic

O F Rabinovich, I M Rabinovich, B V Pinegin

    Stomatologiia
    |October 13, 2004
    PubMed

    Clinical and immunological efficiency of leukinferone in combination with polyoxidonium (immunomodulator) was studied in patients with relapsing herpetic stomatitis (RHS). The levels of alpha- and gamma-IFN were decreased, levels of IgM, IgG, and IgE were increased, active oxygen forms were actively produced, and the count of CD8(+)-cells was increased in patients with RHS. Treatment with polyoxidonium and leukinferone led to an increase of the blood levels of alpha- and gamma-IFN, decrease of IgM, IgG, and IgE levels, normalization of phagocytosis, and decrease of CD8(+)-cell count. The treatment had a pronounced clinical effect in patients with RHS of any severity, which indicates the efficiency of these drugs in combined therapy of patients with RHS.

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