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Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
[Experience of using bacteriophages in the complex treatment of children with aphthous stomatitis]
I M Rabinovich1, O S Gileva2, G M Akmalova3
1Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of the Russian Federation, Moscow, Russia.
Abstract:
Aphthous stomatitis (AS) is one of the most common diseases of the oral mucosa in children. A significant role in the pathogenesis of AS is assigned to the infectious-allergic factor.
The Aim:
Of the work was to evaluate the clinical effectiveness of topical application of bacteriophages in the complex treatment of children with aphthous stomatitis.
Materials And Methods:
The main group included 30 children with AS aged 4 to 15 years. The control group consisted of 20 healthy children without AS and without concomitant somatic pathology at the age of 4 to 15 years. The effectiveness of the therapy was evaluated based on the results of repeated bacteriological examination of the oral microflora, conducted 1 month after phage treatment, as well as the dynamics of clinical manifestations: reduction in size or complete epithelization of defects.
Results:
The use of bacteriophage in the complex treatment of children with AS was accompanied by positive dynamics of clinical and laboratory parameters in all patients: a significant decrease in microbial contamination and the number of individual pathogenic microflora species against the background of normalization of local microbiocenosis in the oral cavity.
Conclusion:
The obtained clinical and laboratory data allowed improving the scheme of complex treatment of AS in children by the use of bacteriophages.
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