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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

The emerging role of lipoproteins in atherogenesis: beyond LDL cholesterol

Stephen Nicholls1, Pia Lundman

  • 1Heart Research Institute, Sydney, Australia.

Seminars in Vascular Medicine
|October 13, 2004
PubMed

Insights

Despite effective low-density lipoprotein cholesterol lowering, cardiovascular events persist. Additional dyslipidemic states, like the atherogenic lipoprotein phenotype, significantly impact arterial health and are key targets for preventing atherosclerotic cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • Low-density lipoprotein cholesterol (LDL-C) is a known factor in atherogenesis and coronary heart disease.
  • Despite effective LDL-C reduction, many patients still experience cardiovascular events, indicating other contributing factors.
  • Emerging evidence highlights additional dyslipidemic states that promote atherosclerosis.

Purpose of the Study:

  • To investigate the role of dyslipidemic states beyond LDL-C in atherogenesis.
  • To identify key components of the atherogenic lipoprotein phenotype.
  • To establish these factors as targets for preventing atherosclerotic cardiovascular disease.

Main Methods:

  • Analysis of dyslipidemic states contributing to cardiovascular events.
  • Characterization of the atherogenic lipoprotein phenotype.
  • Evaluation of the impact of specific lipid parameters on arterial health.

Main Results:

  • The atherogenic lipoprotein phenotype includes elevated triglycerides and triglyceride-rich lipoproteins.
  • This phenotype is characterized by decreased high-density lipoprotein cholesterol concentrations.
  • Increased small, dense low-density lipoprotein cholesterol and impaired postprandial lipemia are also key features impacting the arterial wall.

Conclusions:

  • The atherogenic lipoprotein phenotype plays a profound role in promoting atherosclerosis.
  • These dyslipidemic factors are crucial targets for developing effective prevention strategies.
  • Addressing these factors is essential for reducing cardiovascular events in at-risk patients.

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