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Fibrin D-dimer and cardiovascular risk.
1Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
Seminars in Vascular Medicine
|November 23, 2005
Summary
Fibrin D-dimer assays, used to detect blood clot formation and breakdown, are linked to cardiovascular disease risks. Further research is needed to confirm D-dimer
Area of Science:
- Cardiovascular Medicine
- Hematology
- Clinical Chemistry
Background:
- Fibrin D-dimer is a key biomarker for detecting coagulation activation and fibrinolysis in blood.
- Previous studies over 15 years have associated D-dimer levels with increased cardiovascular disease (CVD) risks.
Purpose of the Study:
- To review the analytic, preanalytic, and clinical associations of Fibrin D-dimer.
- To explore the role of D-dimer in various thromboembolic conditions and cardiovascular risk prediction.
Main Methods:
- Comprehensive literature review of studies on Fibrin D-dimer and cardiovascular diseases.
- Analysis of associations between D-dimer and risk factors, coronary heart disease, atrial fibrillation, stroke, peripheral arterial disease, and venous thromboembolism.
Main Results:
- D-dimer is associated with risks of coronary heart disease, atrial fibrillation, stroke, peripheral arterial disease, and venous thromboembolism.
- These findings suggest that activated coagulation and fibrinolysis may contribute to arterial, intracardiac, and venous thromboembolism.
Conclusions:
- Fibrin D-dimer shows potential utility in predicting cardiovascular risk and identifying patients for anticoagulation therapy.
- Further studies are required to validate D-dimer's clinical utility, and assay harmonization is crucial for improved clinical application.