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Fibrin D-dimer and cardiovascular risk

Gordon D O Lowe1

  • 1Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Seminars in Vascular Medicine
|November 23, 2005
PubMed

Insights

Fibrin D-dimer assays, used to detect blood clot formation and breakdown, are linked to cardiovascular disease risks. Further research is needed to confirm D-dimer

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Clinical Chemistry

Background:

  • Fibrin D-dimer is a key biomarker for detecting coagulation activation and fibrinolysis in blood.
  • Previous studies over 15 years have associated D-dimer levels with increased cardiovascular disease (CVD) risks.

Purpose of the Study:

  • To review the analytic, preanalytic, and clinical associations of Fibrin D-dimer.
  • To explore the role of D-dimer in various thromboembolic conditions and cardiovascular risk prediction.

Main Methods:

  • Comprehensive literature review of studies on Fibrin D-dimer and cardiovascular diseases.
  • Analysis of associations between D-dimer and risk factors, coronary heart disease, atrial fibrillation, stroke, peripheral arterial disease, and venous thromboembolism.

Main Results:

  • D-dimer is associated with risks of coronary heart disease, atrial fibrillation, stroke, peripheral arterial disease, and venous thromboembolism.
  • These findings suggest that activated coagulation and fibrinolysis may contribute to arterial, intracardiac, and venous thromboembolism.

Conclusions:

  • Fibrin D-dimer shows potential utility in predicting cardiovascular risk and identifying patients for anticoagulation therapy.
  • Further studies are required to validate D-dimer's clinical utility, and assay harmonization is crucial for improved clinical application.

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