[The tissue and cellular reactions of the lung in drug-resistant tuberculosis]

The material obtained from 52 patients with drug-resistant fibrocavernous pulmonary tuberculosis was studied. Morphological studies established the progression of a process in 94.2% of the cases. There was a prevalence of an alternatively exudative tissue reaction, a generalization of the process with specific and non-specific changes in the lung, lesion to the vascular bed with a predominance of an exudative reaction, generalized nonspecific and specific bronchitis with impaired elimination of the intraalveolar contents and with the preserved extensive cellular infiltrates in the lung. Healing elements as the signs of the encapsulation of caseous necrosis, the proliferation of lymphoid elements, and a macrophageal response were simultaneously revealed, which provides evidence for that different modalities of pathogenetic therapy should be used.