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Published on: August 7, 2017
Breast-feeding reduces the risk of asthma during the first 4 years of life
Inger Kull1, Catarina Almqvist, Gunnar Lilja
1Department of Occupational and Environmental Health, Stockholm County Council, Sweden. inger.kull@sma.sll.se
Insights
Breast-feeding, particularly exclusive for four months, significantly lowers a child's risk of developing asthma by age four. This protective effect holds true regardless of allergies and may be stronger in children without a family history of asthma.
Area of Science:
- Pediatric Allergy and Immunology
- Epidemiology
- Public Health
Background:
- The role of breastfeeding in preventing childhood asthma remains unclear.
- Existing evidence on breastfeeding's protective effect against allergic diseases is inconclusive.
Purpose of the Study:
- To investigate the impact of breastfeeding on asthma development and allergen sensitization in children up to four years old.
- To analyze the relationship between breastfeeding duration and intensity and the incidence of asthma and allergic sensitization.
Main Methods:
- A birth cohort study followed 4089 children, collecting breastfeeding exposure data at 2 months and 1 year.
- Total breast milk dose was calculated from exclusive and partial breastfeeding periods.
- Asthma and sensitization outcomes were assessed at 1, 2, and 4 years, including clinical investigations and specific IgE analysis.
Main Results:
- Exclusive breastfeeding for ≥4 months reduced asthma risk by age 4 (OR 0.72).
- Excluding children with wheeze during lactation strengthened this protective effect (OR 0.64).
- Combined exclusive (3-4 months) and partial (≥3 months) breastfeeding showed significant asthma risk reduction (OR 0.44).
Conclusions:
- Breastfeeding demonstrably reduces the risk of asthma in children within the first four years of life.
- The findings support breastfeeding as a key preventive strategy for childhood asthma.
Background:
The evidence for a preventive effect of breast-feeding on asthma and other allergic diseases in childhood is inconclusive.
Objective:
The aim of this study was to investigate the effect of breast-feeding on asthma and sensitization to airborne allergens among children up to 4 years of age.
Methods:
A birth cohort of 4089 children was followed. Exposure data were collected at 2 months and 1 year of age. The total dose of breast milk was estimated by combining periods of exclusive and partial breast-feeding. Outcomes data were collected at 1, 2, and 4 years of age. The response rate at 4 years was 90%, and 73% participated in a clinical investigation, including blood sampling for analysis of specific IgE and lung function testing. Children with onset of wheeze during lactation (n=217) were excluded in some of the analyses to avoid disease-related modification of exposure.
Results:
Exclusive breast-feeding for 4 months or more reduced the risk of asthma at the age of 4 years (odds ratio [OR], 0.72; 95% CI, 0.53-0.97), irrespective of sensitization to common airborne allergens ( P=.72). Excluding children with wheeze during lactation tended to strengthen the risk estimate (OR, 0.64; 95% CI, 0.46-0.88). A duration of 3 months or more of partial breast-feeding seemed to offer additional protection; exclusive breast-feeding for 3 to 4 months combined with partial breast-feeding for 3 months or more resulted in an OR of 0.44 (95% CI, 0.21-0.87). The effects tended to be stronger in children without heredity for allergy ( P interaction=.36).
Conclusion:
Breast-feeding reduces the risk of asthma during the first 4 years of life.
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