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Related Experiment Videos

Amebic meningoencephalitis in a sheep.

I C Fuentealba1, S E Wikse, W K Read

  • 1Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4463.

Journal of the American Veterinary Medical Association
|February 1, 1992
PubMed
Summary
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A Suffolk ewe experienced sudden incoordination and blindness. Necropsy revealed amebic encephalitis caused by Leptomyxid species, a rare pathogen in sheep.

Area of Science:

  • Veterinary Pathology
  • Parasitology
  • Neurology

Background:

  • Ovine neurological diseases can present with acute symptoms like incoordination and blindness.
  • Antibiotic treatment is often the first line of therapy for suspected bacterial infections in sheep.

Observation:

  • A 1.5-year-old Suffolk ewe presented with acute incoordination and blindness, unresponsive to antibiotics.
  • Necropsy revealed thickened, opaque meninges and focal hypercellularity in the cerebral gray matter.
  • Microscopic examination showed inflammation (gliosis, perivascular cuffing with eosinophils) and amebic organisms in two life stages.

Findings:

  • Two distinct amebic life stages were identified in the sheep's brain: large trophozoites (15-35 microns) and smaller cysts (10-17 microns).
  • Trophozoites had vacuolated cytoplasm and distinct nuclei with prominent eosinophilic nucleoli.

Related Experiment Videos

  • Immunofluorescence confirmed the presence of amebic antigens, identifying the organism as Leptomyxid sp., a species previously isolated from humans and baboons.

    • Implications:

    • This case highlights Leptomyxid amebas as a potential cause of fatal neurological disease in sheep.
    • The findings suggest a possible zoonotic or cross-species transmission risk for Leptomyxid amebas.
    • Further research is needed to understand the epidemiology and transmission of Leptomyxid species in livestock.