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Updated: Aug 21, 2026

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Published on: January 6, 2016
Significance of nuclear phospholipase C signaling through type 1 IGF receptor
L Cocco1, S Capitani, N M Maraldi
1Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Bologna, Italy. lcocco@biocfarm.unibo.it
Abstract:
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation. Here we shall review the main features of nuclear inositol lipid signaling through type I IGF receptor, focusing the attention on the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, given its peculiar localization in the nuclear compartment.
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