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Updated: Aug 21, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Bone remodeling analysis of various dental implant surfaces using polyfluorochrome sequential labeling in rabbit
Claudia de Carvalho Lopes1, Bruno König Júnior, Marcelo José Carbonari
1Department of Functional Anatomy, Structure and Ultra-Structure, Institute of Biomedical Sciences, University of São Paulo. Av. Lineu Prestes 2514, Cidade Universitária 05508-900, São Paulo, SP, Brasil.
Abstract:
The purpose of this study is to analyze the bone remodeling process after the placement of threaded implants with rough (RBM) and hydroxyapatite coated surfaces (HA) in rabbit tibias using polyfluorochrome sequential labeling. Histomorphometry was performed in order to quantify the amount of each label deposited during the healing period. This work demonstrates the possibility of periodic identification of apatite deposition during bone remodeling around titanium and ceramic implants. It has been concluded that the polyfluorochrome sequential labeling is an important tool for identification of bone remodeling after the insertion of titanium and ceramic implants inside rabbit tibias.
