Related Experiment Video
Updated: Aug 17, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Oocyte quality in patients with severe ovarian hyperstimulation syndrome: a self-controlled clinical study
Francisco Fábregues1, Joana Peñarrubia, Ester Vidal
1Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Objective:
To investigate the oocyte quality in patients with severe ovarian hyperstimulation syndrome (OHSS).
Design:
Self-controlled clinical study.
Setting:
University teaching hospital.
Patient(S):
Twenty-two patients from our assisted reproductive technology (ART) program who developed severe OHSS during their first controlled ovarian hyperstimulation for IVF or intracytoplasmic sperm injection (ICSI) (OHSS cycles) during a period of 10 years and had a second ART attempt performed in our center in which OHSS did not develop (control cycles).
Intervention(S):
IVF and ICSI.
Main Outcome Measure(S):
Oocyte yield and quality, fertilization rate, embryo yield and quality, implantation rate, and pregnancy rate.
Result(S):
The total number of oocytes retrieved and the mean number of metaphase II oocytes were significantly higher in patients with OHSS than in control cycles. Fertilization rates were similar in both groups of ART cycles, and thus the number of viable embryos were significantly higher in OHSS cycles. Implantation and pregnancy rates were similar in OHSS and control cycles. Oocyte and embryo yield and quality were similar in early and late OHSS. Oocyte yield and quality, embryological outcome, and implantation and pregnancy rates were similar in patients with and without polycystic ovarian syndrome (PCOS) both in cycles developing OHSS and control cycles.
Conclusion(S):
Oocyte quality is not compromised in severe OHSS cycles irrespective of whether patients had or did not have PCOS.
