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Related Experiment Videos

Bupropion SR for relapse prevention: a "slips-allowed" analysis.

Michael J Durcan1, J Andrew Johnston, Jonathan White

  • 1Smoking Control, GlaxoSmithKline, 1500 Littleton Road, Parsippany, NJ 07054, USA. Michael.J.Durcan@GSK.com

American Journal of Health Behavior
|October 16, 2004
PubMed
Summary

Bupropion SR significantly extends smoking abstinence duration, with a "slips allowed" analysis showing longer relapse-free periods compared to traditional methods. This medication is effective for preventing smoking relapse.

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Psychology

Background:

  • Smoking cessation remains a significant public health challenge.
  • Relapse prevention is a critical component of successful smoking cessation.
  • Traditional analyses may overestimate relapse rates by not accounting for brief slips.

Purpose of the Study:

  • To evaluate the effectiveness of sustained-release bupropion (bupropion SR) in maintaining smoking abstinence.
  • To compare the efficacy of bupropion SR using a "slips allowed" analysis versus a traditional analysis.

Main Methods:

  • Retrospective analysis of data from a multicenter, randomized, double-blind, placebo-controlled trial.
  • The "slips allowed" analysis defined relapse differently than traditional methods, not considering brief smoking episodes as a return to regular smoking.

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Main Results:

  • Median time to relapse was 65 weeks for bupropion SR versus 30 weeks for placebo when using a "slips allowed" analysis.
  • In contrast, traditional analysis showed median times to relapse of 32 weeks for bupropion SR and 20 weeks for placebo.
  • The "slips allowed" analysis indicated a more substantial and prolonged effect of bupropion SR on preventing relapse.

Conclusions:

  • Bupropion SR demonstrates significant efficacy in preventing smoking relapse.
  • A "slips allowed" analysis offers a more clinically relevant and potentially less conservative measure of smoking cessation treatment efficacy.