Related Experiment Video
Updated: Jan 16, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Markov Modeling to Estimate the Population Impact of Emerging Tobacco Products: A Proof-of-Concept Study
Caroline O Cobb1, Andrea C Villanti1, Amanda L Graham1
1Caroline O. Cobb, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Andrea C. Villanti, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Amanda L. Graham, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Jennifer L. Pearson, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Allison M. Glasser, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Jessica M. Rath, Department of Evaluation Science and Research, Legacy, Washington, DC. Cassandra A. Stanton, Westat, Rockville, MD. David T. Levy, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC. David B. Abrams, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC. Raymond Niaura, The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC.
Objectives:
To develop a modeling tool to assess the population impact of emerging tobacco products and demonstrate its utility.
Methods:
Discrete state Markov models were developed using TreeAge Pro 2014 to operationalize and estimate current cigarette and e-cigarette use patterns in the US population (including never and former use). State transition probabilities were calculated from a longitudinal survey of US young adults and adjusted using other nationally representative data.
Results:
Over 10 years, the adjusted base case model approximated national cigarette smoking and former use prevalence and predicted e-cigarette and dual use prevalence between 1% and 2%.
Conclusions:
This proof-of-concept study provides a heuristic tool to operationalize aspects of the US Food and Drug Administration's new public health standard regarding the impact of new tobacco products on use of existing products.
More Related Videos
09:25Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Mechanistic Models: Compartment Models in Individual and Population Analysis
Analysis of Population Pharmacokinetic Data
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...