Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Checking out the centrosome.

Alwin Krämer1, Jiri Lukas, Jiri Bartek

  • 1Danish Cancer Society, Institute of Cancer Biology, Department of Cell Cycle and Cancer, Copenhagen, Denmark.

Cell Cycle (Georgetown, Tex.)
|October 16, 2004
PubMed
Summary

Centrosomes, crucial for cell division, integrate pathways regulating entry into mitosis. Recent research clarifies their role beyond organizing microtubules, linking them to cell cycle control and DNA damage monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<sup>68</sup>Ga-FAPI-PET/CT in extra-cervical CUP: Head-to-Head Comparison of <sup>68</sup>Ga-FAPI-46 with <sup>18</sup>F-FDG in 13 patients.

European journal of nuclear medicine and molecular imaging·2026
Same author

(Un-)Known Chances: Emerging Hope for Cancer of Unknown Primary - Highlights from ESMO 2025 and the First International Cancer of Unknown Primary Meeting.

Oncology research and treatment·2026
Same author

Etiology of TP53 mutated complex karyotype acute myeloid leukemia.

Leukemia·2025
Same author

Azacitidine to treat measurable residual disease in patients with MDS/AML: final long-term results of the RELAZA2 trial.

Blood·2025
Same author

Rethinking cancer of unknown primary: from diagnostic challenge to targeted treatment.

Nature reviews. Clinical oncology·2025
Same author

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.

Nature genetics·2024

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Centrosomes, composed of centrioles and pericentriolar matrix, organize microtubule arrays.
  • Established functions include cell polarity and mitotic spindle formation for chromosome segregation.

Purpose of the Study:

  • To review recent advances in understanding centrosome functions.
  • To explore the role of centrosomes in integrating regulatory pathways for mitotic entry.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of centrosome-associated regulatory proteins and their functions.

Main Results:

  • Centrosomes are implicated in cell cycle regulation, including mitosis entry, cytokinesis, and DNA damage.
  • Numerous regulatory proteins (e.g., p53, Aurora-A, Plk1) localize to centrosomes.
  • Direct functional links between centrosome localization and cellular events are increasingly being uncovered.

Conclusions:

  • Centrosomes act as key integrators of signaling pathways that control cell cycle progression.
  • Emerging evidence highlights centrosomes' expanded role in cell cycle regulation beyond microtubule organization.

Related Experiment Videos