Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting proximal advanced neoplasms at screening sigmoidoscopy.

Carlo Senore1, Nereo Segnan, Luigina Bonelli

  • 1Unit of Epidemiology, CPO, Piemonte, Torino, Italy. carlo.senore@cpo.it

Diseases of the Colon and Rectum
|October 16, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing bowel preparation regimens for colon capsule endoscopy: an umbrella review (overview of systematic reviews).

Therapeutic advances in gastrointestinal endoscopy·2026
Same author

Resource Use and Costs of the Low-risk Arm of a Risk-stratified Colorectal Cancer Screening Approach Based on Previous Negative FIT Values: Comparative Analyses With the Standard Approach.

Clinical colorectal cancer·2026
Same author

Fecal immunochemical tests from population-based colorectal cancer screening programs support prospective microbiome cohorts.

British journal of cancer·2026
Same author

Improving EU cancer screening policies: A framework for identifying barriers of screening programs with monitoring data.

Journal of cancer policy·2026
Same author

Population-Based First Estimates of the Effect of HPV Vaccination in Three Italian Areas Covered by Organised Cervical Screening.

International journal of cancer·2026
Same author

Risk-stratified cancer screening: A consensus-based conceptual framework from EUCanScreen.

European journal of cancer (Oxford, England : 1990)·2026

Characteristics of distal polyps can predict advanced proximal neoplasms. High-risk distal polyps indicate a higher likelihood of advanced proximal neoplasia, suggesting a targeted colonoscopy strategy for cost-effectiveness in colorectal cancer screening.

Area of Science:

  • Gastroenterology
  • Oncology
  • Preventive Medicine

Background:

  • Colorectal cancer (CRC) screening aims to detect neoplasms early.
  • Identifying predictive markers for advanced proximal neoplasms is crucial for efficient screening.
  • Distal polyps may serve as indicators for proximal lesions.

Purpose of the Study:

  • To evaluate the predictive value of distal polyp characteristics for advanced proximal neoplasms.
  • To assess the association between distal polyp risk categories and the presence of advanced proximal neoplasia.

Main Methods:

  • A cohort of 55-64 year olds referred for colonoscopy was analyzed.
  • Patients with a history of CRC, adenomas, IBD, or strong family history were excluded.
  • Prevalence of advanced proximal neoplasia was compared between patients with low-risk and high-risk distal polyps.

Related Experiment Videos

Main Results:

  • Among 426 patients with polyps > 5 mm, 6.9% had advanced proximal neoplasms.
  • Prevalence was 9.4% in high-risk distal polyp group vs. 2.5% in low-risk group (aOR 3.19).
  • 10 patients with high-risk distal polyps needed colonoscopy per proximal neoplasm detected, versus 40 for low-risk.

Conclusions:

  • Low-risk distal polyps (6-9 mm) showed a similar prevalence of advanced proximal neoplasms as individuals without distal polyps.
  • Focusing colonoscopy referrals on patients with high-risk distal polyps may be a cost-effective screening approach.
  • This strategy could optimize resource allocation in CRC screening programs.