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Adverse reactions to voriconazole

Aileen E Boyd1, Simon Modi, Susan J Howard

  • 1Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 16, 2004
PubMed

Insights

High voriconazole concentrations can cause toxicity in patients with invasive aspergillosis. Monitoring plasma levels may help optimize voriconazole dosing for better patient outcomes.

Area of Science:

  • Medical Mycology
  • Clinical Pharmacology

Background:

  • Voriconazole is a key antifungal medication for invasive aspergillosis.
  • Significant interpatient variability exists in voriconazole plasma concentrations.

Observation:

  • Three patients experienced diverse toxicities, including neurological and metabolic disturbances.
  • These adverse events were potentially linked to elevated voriconazole levels.

Findings:

  • High voriconazole plasma concentrations are associated with serious adverse events.
  • Toxicity manifestations were varied, impacting multiple organ systems.

Implications:

  • Therapeutic drug monitoring of voriconazole is crucial.
  • Optimizing voriconazole dosage can mitigate toxicity and improve treatment efficacy.

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