Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central regulation of ejaculation.

Lique M Coolen1, Julien Allard, William A Truitt

  • 1Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, OH 45267-0521, USA. lique.coolen@uc.edu

Physiology & Behavior
|October 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative management of scheduled interventional neuroradiology procedures: Results of a nationwide French survey.

Journal of neuroradiology = Journal de neuroradiologie·2026
Same author

Effect of Stenosis Severity on Outcomes After Rescue Stenting for Acute Middle Cerebral Artery Occlusions: a Real-world Multicenter Analysis.

Clinical neuroradiology·2026
Same author

IV Tenecteplase Before Thrombectomy Compared With Thrombectomy Alone in Patients With Stroke Due to a Large Vessel Occlusion.

Neurology·2026
Same author

Tenecteplase versus Alteplase as Bridging Thrombolysis before Mechanical Thrombectomy for Medium and Distal Vessel Occlusions.

AJNR. American journal of neuroradiology·2026
Same author

Cone beam CT-guided biopsy of a petrous apex lesion via the contralateral subzygomatic transclival approach.

Journal of neurointerventional surgery·2026
Same author

Intravenous Thrombolysis Use in the Late Time Window Before Interhospital Transfer for Thrombectomy.

JAMA neurology·2025
Same journal

Importance of Apparatus Scaling in Novel Object Recognition for Juvenile and Adult Rats.

Physiology & behavior·2026
Same journal

Chronic activity-based anorexia alters food intake microstructure in a time-dependent manner in female rats.

Physiology & behavior·2026
Same journal

Apelin receptor antagonist (ML221) facilitates memory reconsolidation in novel object recognition task.

Physiology & behavior·2026
Same journal

Are humans adapted to the world they have developed?

Physiology & behavior·2026
Same journal

50-kHz ultrasonic vocalization subtypes emitted by female rats anticipating same-sex social interaction.

Physiology & behavior·2026
Same journal

Sex-dependent behavioral and prefrontal BDNF mRNA responses to extinction training and short-term citalopram after fear conditioning in rats.

Physiology & behavior·2026
See all related articles

Researchers identified lumbar spinothalamic (LSt) cells as crucial for the spinal ejaculation generator, coordinating reflex phases and integrating sensory input for male reproductive function.

Area of Science:

  • Neuroscience
  • Reproductive Biology
  • Physiology

Background:

  • Ejaculation is a complex reflex controlled by a spinal ejaculation generator.
  • This generator coordinates autonomic and motor functions for emission and expulsion.
  • Supraspinal sites like the nPGi, PVN, and MPOA modulate this generator.

Purpose of the Study:

  • To investigate the role of lumbar spinothalamic (LSt) cells in the spinal ejaculation generator.
  • To understand how LSt cells integrate sensory information and control ejaculatory function.
  • To identify neural pathways involved in processing ejaculation-related cues.

Main Methods:

  • Lesion studies targeting LSt cells in the lumbar spinal cord.
  • Analysis of LSt cell activation patterns during sexual behavior.

Related Experiment Videos

  • Examination of anatomical connections between LSt cells and relevant neural nuclei.
  • Investigation of potential pathways for relaying ejaculation-related sensory information.

    • Main Results:

    • Lesions of LSt cells completely abolished ejaculatory function.
    • LSt cells showed activation specifically after ejaculation, not other sexual behaviors.
    • LSt cells are anatomically positioned to integrate genital sensory inputs with autonomic and motor pathways.
    • A pathway involving LSt cells and projections to the thalamus was identified as a candidate for relaying ejaculation cues.

    Conclusions:

    • Lumbar spinothalamic (LSt) cells are integral components of the spinal ejaculation generator.
    • LSt cells play a critical role in coordinating the reflex and integrating sensory information for ejaculation.
    • Neural pathways involving LSt cells are likely involved in processing ejaculation-related sensory cues and potentially their rewarding properties.