Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Yeast replicative life span--the mitochondrial connection.

S Michal Jazwinski1

  • 1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7-2, New Orleans, LA 70112, USA.

FEMS Yeast Research
|October 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practical Memory Concerns in Oldest-Old Adults.

International journal of aging & human development·2026
Same author

Beyond hallmarks of aging - biological age and emergence of aging networks.

Aging pathobiology and therapeutics·2025
Same author

Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide.

American journal of cancer research·2025
Same author

Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease.

Nature communications·2025
Same author

BATF-dependent Th17 cells act through the IL-23R pathway to promote prostate adenocarcinoma initiation and progression.

Journal of the National Cancer Institute·2024
Same author

Spatial Dissection of the Distinct Cellular Responses to Normal Aging and Alzheimer's Disease in Human Prefrontal Cortex at Single-Nucleus Resolution.

medRxiv : the preprint server for health sciences·2024
Same journal

Yeasts in the Gastrointestinal Tract.

FEMS yeast research·2026
Same journal

Nutrient sensing and transceptor-mediated metabolic control in yeast.

FEMS yeast research·2026
Same journal

Establishment of a Protoplast Transformation Method in the Oleaginous Yeast Rhodotorula toruloides.

FEMS yeast research·2026
Same journal

The oxidative cost of losing low temperature viability protein 1 [Ltv1]: insights into cellular damage and homeostasis.

FEMS yeast research·2026
Same journal

Systems biology of yeast metabolism.

FEMS yeast research·2026
Same journal

Uncorking wine yeast genomics from grape to glass.

FEMS yeast research·2026
See all related articles

Mitochondria play a key role in yeast aging. Activating the retrograde response extends lifespan by signaling mitochondrial dysfunction, despite paradoxically increasing genome-damaging circles.

Area of Science:

  • Cellular Biology
  • Aging Research
  • Yeast Genetics

Background:

  • Mitochondria are linked to aging via reactive oxygen species.
  • The retrograde response pathway signals mitochondrial dysfunction.
  • Mitochondria influence aging asymmetry between mother and daughter yeast cells.

Purpose of the Study:

  • To investigate the multifaceted role of mitochondria in Saccharomyces cerevisiae longevity and aging.
  • To explore the connection between the retrograde response, mitochondrial dysfunction, and lifespan extension.
  • To understand how mitochondrial integrity and function impact cellular aging processes.

Main Methods:

  • Induction of the retrograde response pathway.
  • Analysis of extrachromosomal ribosomal DNA circle (ERC) production.

Related Experiment Videos

  • Investigating the function of RTG2, PHB1, PHB2, and Ras2p genes.
  • Assessing mitochondrial membrane potential and metabolic intermediates.

    • Main Results:

    • The retrograde response extends yeast lifespan and delays aging, altering cellular metabolism and stress resistance.
    • RTG2 gene links retrograde response-induced mitochondrial dysfunction to ERC production, impacting genome stability.
    • Prohibitins (Phb1/2) maintain mitochondrial protein production balance, preventing short-lived cell formation; Ras2p influences this.
    • Mitochondrial membrane potential and Krebs cycle intermediates are vital for yeast longevity.

    Conclusions:

    • Mitochondria are central to yeast longevity and aging processes.
    • The retrograde response offers a mechanism for lifespan extension but carries risks like ERC accumulation.
    • Mechanisms exist to filter damaged components, ensuring daughter cell health and contributing to age asymmetry.