Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

WormBase as an integrated platform for the C. elegans ORFeome.

Nansheng Chen1, Daniel Lawson, Keith Bradnam

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. chenn@cshl.org

Genome Research
|October 19, 2004
PubMed
Summary

The C. elegans ORFeome project provides a valuable resource for proteome studies. Integration with WormBase enhances data accuracy and accessibility for researchers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal Permeability Responses to Maximal and Submaximal Exercise in Individuals with Normal-Weight Obesity: An Exploratory Study.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same author

Chromosome-level genome assembly of a cosmopolitan marine harmful algal bloom diatom species Chaetoceros socialis (Chaetocerotaceae).

Scientific data·2026
Same author

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

Nature·2026
Same author

A high-quality chromosome-level genome assembly of a feather star Glyptometra sp. from a deep seamount.

Scientific data·2026
Same author

HAB species of the Bohai Sea detected through metabarcoding in three large-scale seasonal expeditions.

Harmful algae·2026
Same author

Comparative evaluation of 18S rDNA V4 and 28S rDNA D1-2 regions for resolving Alexandrium species diversity to improve its use for metabarcoding.

Harmful algae·2026

Area of Science:

  • * Genomics and Bioinformatics
  • * Molecular Biology
  • * Nematode Research

Background:

  • * The ORFeome project has generated a comprehensive set of validated gene models for *C. elegans*.
  • * Large-scale 'omics' datasets often contain false positives and negatives, necessitating data integration for validation.
  • * Existing data repositories lack comprehensive integration of ORFeome data with other critical *C. elegans* datasets.

Purpose of the Study:

  • * To describe the integration of *C. elegans* ORFeome data into WormBase.
  • * To enhance the utility of ORFeome data for the research and teaching community.
  • * To improve the accuracy and confidence of *C. elegans* gene models.

Main Methods:

  • * Deposition of *C. elegans* ORFeome data into the WormBase database.

Related Experiment Videos

  • * Cross-referencing ORFeome data with genome, transcriptome, and other large-scale datasets.
  • * Development of visualization tools within WormBase to display integrated data.
  • * Establishing links between WormBase and the ORFeome project's reagent resources.

    • Main Results:

    • * Successful integration of *C. elegans* ORFeome data into WormBase.
    • * Demonstrated use of integrated data to correct and validate predicted gene models.
    • * Enhanced accessibility of validated ORFeome data within the context of other biological datasets.
    • * Established a robust platform for comparative analysis and confidence assessment of 'omics' data.

    Conclusions:

    • * WormBase serves as a crucial platform for integrating and validating large-scale biological data.
    • * Data integration significantly improves the reliability and utility of the *C. elegans* ORFeome resource.
    • * This integrated approach facilitates proteome-scale studies and advances *C. elegans* research.