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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Related Experiment Video

Updated: Jul 15, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Intestinal Permeability Responses to Maximal and Submaximal Exercise in Individuals with Normal-Weight Obesity: An

Bryant H Keirns1, Ashley Keller2, Alexis R Quirk1

  • 1Department of Nutrition and Health Science, Ball State University, Muncie, IN.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|July 13, 2026
PubMed
Summary

Normal-weight obesity individuals show similar gut permeability responses to exercise as lean and obese groups. Further research is needed to understand how body fat influences exercise-induced gut barrier changes.

Keywords:
aerobic exercisegut barrierintestinal permeabilitynormal-weight obesityobesity

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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
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Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jul 15, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

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Published on: October 17, 2018

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
06:13

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Area of Science:

  • Exercise physiology
  • Gastroenterology
  • Cardiovascular disease research

Background:

  • Intestinal permeability is linked to inflammation and cardiovascular disease (CVD).
  • Aerobic exercise can increase intestinal permeability, but responses in at-risk groups are unknown.
  • Normal-weight obesity (NWO) presents increased CVD risk, potentially due to inflammation, with unclear drivers.

Purpose of the Study:

  • To investigate gut permeability and inflammatory biomarker responses to maximal and submaximal exercise in normal-weight obese (NWO) individuals.
  • To compare these responses between NWO, normal-weight lean (NWL), and obese (OB) groups.
  • To explore the relationship between body fat percentage and exercise-induced changes in gut biomarkers.

Main Methods:

  • Cross-sectional study involving 31 participants (NWO, NWL, OB).
  • Participants underwent maximal exercise testing (T1) and submaximal exercise (T2) on a cycle ergometer.
  • Gut permeability (FABP2) and inflammatory (sCD14, IL-6) biomarkers were measured pre- and post-exercise.

Main Results:

  • sCD14 increased post-maximal exercise in the full sample, NWL, and OB groups.
  • FABP2 increased post-maximal exercise in NWO and post-submaximal exercise in the full sample and OB group.
  • IL-6 increased post-submaximal exercise in all groups, with similar absolute changes across groups for all biomarkers.

Conclusions:

  • NWO individuals exhibit largely similar gut barrier responses to exercise compared to NWL and OB groups.
  • Preliminary findings suggest potential minor differences in specific biomarker responses.
  • The impact of relative adiposity on exercise-induced intestinal permeability requires further investigation.