Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variation after a selective sweep in a subdivided population.

Enrique Santiago1, Armando Caballero

  • 1Departamento de Biología Funcional, Facultad de Biología, Universidad de Oviedo, 33071 Oviedo, Spain. esr@uniovi.es

Genetics
|October 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.

Genetics·2026
Same author

Inbreeding load in finite populations from dominant and overdominant mutations.

Proceedings. Biological sciences·2025
Same author

Accounting for population structure and data quality in demographic inference with linkage disequilibrium methods.

Nature communications·2025
Same author

Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers.

Evolutionary applications·2025
Same author

A Test of the Long-Term Efficiency of Genetic Rescue With Drosophila melanogaster.

Molecular ecology·2025
Same author

Impact of population structure in the estimation of recent historical effective population size by the software GONE.

Genetics, selection, evolution : GSE·2023

Genetic hitchhiking impacts neutral variation differently across subpopulations. While linked variation decreases where a mutation arises, it can increase in other demes, altering gene frequency spectra.

Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Molecular Evolution

Background:

  • Genetic hitchhiking describes the process where neutral genetic variation is affected by the fixation of a beneficial mutation.
  • Subdivided populations with distinct demes exhibit complex responses to selective sweeps.

Purpose of the Study:

  • To analyze the effect of genetic hitchhiking on neutral variation in subdivided populations.
  • To investigate how migration of a favorable mutation influences neutral variation in different subpopulations.

Main Methods:

  • Analytical derivations were employed to model the effects.
  • Computer simulations were utilized to validate the analytical findings.

Main Results:

Related Experiment Videos

  • Reduced variation around the selected locus is smaller than predicted in panmictic populations.
  • Neutral loci distant from the selected site can increase in variation.
  • Gene frequency spectra at these loci show an excess of intermediate-frequency alleles.

    • Conclusions:

    • Genetic hitchhiking in subdivided populations can redistribute variation, increasing it at distant neutral loci.
    • This mechanism highlights complex evolutionary dynamics beyond classical hitchhiking predictions.
    • The findings apply to various systems with clustered genetic variation and limited exchange.