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The road to Src

G Steven Martin1

  • 1University of California at Berkeley, Department of Molecular and Cell Biology, 16 Barker Hall # 3204, Berkeley, CA 94720-3204, USA. smartin@socrates.berkeley.edu

Oncogene
|October 19, 2004
PubMed

Insights

The discovery of the c-src proto-oncogene, crucial for understanding cancer, stemmed from research on Rous sarcoma virus (RSV). This work paved the way for targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Virology

Background:

  • The c-src proto-oncogene was identified over 25 years ago.
  • Cancer development involves mutations in proto-oncogenes and tumor suppressor genes.
  • Research on Rous sarcoma virus (RSV) laid the groundwork for understanding c-src.

Purpose of the Study:

  • To review the historical research leading to the identification of the RSV transforming gene.
  • To explain how this research contributed to the discovery of cellular Src.

Main Methods:

  • Historical review of scientific literature.
  • Analysis of research on avian RNA tumor viruses, specifically RSV.

Main Results:

  • Decades of study on RSV led to the identification of its transforming gene and protein.
  • This discovery facilitated the identification of the cellular Src proto-oncogene.

Conclusions:

  • The identification of c-src is a landmark achievement in cancer research.
  • Understanding oncogenes like c-src has enabled the development of targeted cancer therapies.

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