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Updated: Aug 1, 2026

09:14
Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
Published on: May 7, 2019
[Functional morphology of skin ageing]
Advances in Gerontology = Uspekhi Gerontologii
|October 20, 2004
Summary
Skin aging involves intrinsic genetic factors and extrinsic environmental factors like UV radiation, leading to photoaging. This review examines changes in skin layers due to both chronological and photoaging.
Area of Science:
- Dermatology
- Biology
- Genetics
Context:
- Cutaneous aging is a multifaceted biological process.
- Aging comprises intrinsic (genetic) and extrinsic (environmental) factors.
- Ultraviolet (UV) irradiation is a primary extrinsic factor causing photoaging.
Purpose:
- To review the alterations in skin components associated with aging.
- To differentiate between intrinsic aging and extrinsic photoaging.
- To examine the effects of UV exposure on skin structure.
Summary:
- Intrinsic aging is a genetically determined degenerative process.
- Extrinsic aging, or photoaging, results from environmental exposure, primarily UV irradiation.
- Both intrinsic and photoaging affect the epidermis and connective tissue of the skin.
Impact:
- Provides a comprehensive overview of skin aging mechanisms.
- Highlights the significant role of UV radiation in premature skin aging.
- Informs understanding of dermatological changes related to aging and environmental factors.
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