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Electrophysiologic function in the healthy, extremely old.

B S Oken1, J A Kaye

  • 1Department of Neurology, Oregon Health Sciences University, Portland 97201.

Neurology
|March 1, 1992
PubMed
Summary
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Healthy aging significantly impacts electrophysiologic tests of brain function. Conventional EEG, computerized EEG frequency analysis (CEEGFA), and auditory evoked potentials show age-related changes, particularly after age 80.

Area of Science:

  • Neuroscience
  • Gerontology
  • Clinical Electrophysiology

Background:

  • Aging affects cerebral function, necessitating understanding of electrophysiologic changes in healthy older adults.
  • Conventional EEG, CEEGFA, and auditory evoked potentials are key clinical tools for assessing brain function.

Purpose of the Study:

  • To investigate the effects of healthy aging on conventional EEG, CEEGFA, and long-latency auditory evoked potentials.
  • To compare electrophysiologic measures in very elderly subjects (over 84) with younger elderly and younger adults.

Main Methods:

  • Analysis of conventional EEG, CEEGFA, and P3 auditory evoked potentials in 22 subjects aged 84-98.
  • Comparison with younger elderly (age not specified) and adults under 65.
  • Correlation of EEG findings with MRI white matter hyperintensities, blood pressure, and cognitive function.

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Main Results:

  • Intermittent temporal slowing on conventional EEG observed in 50% of the oldest group, linked to white matter hyperintensities.
  • CEEGFA revealed posterior peak frequency decline and significant changes in relative theta, relative alpha, and median-power frequency above age 80.
  • P3 potentials were absent in 5/22 oldest subjects; P3 latency increased with age, while amplitude remained stable until the eighties.

Conclusions:

  • Healthy aging demonstrably alters conventional EEG, CEEGFA, and auditory evoked potentials, especially in individuals over 80.
  • These findings underscore the importance of age-specific normative data for interpreting electrophysiologic tests in the elderly.
  • Electrophysiologic changes correlate with brain structural changes (white matter hyperintensities) but not necessarily cognitive decline in healthy aging.