Related Experiment Video

Updated: Aug 21, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Poor coronary collateral circulation is associated with higher concentrations of soluble adhesion molecules in

Umit Guray1, Ali Riza Erbay, Yesim Guray

  • 1Yüksek Ihtisas Hospital, Cardiology Clinic, Ankara, Turkey. umitguray@hotmail.com

Coronary Artery Disease
|October 20, 2004
PubMed

Insights

Poor coronary collateral circulation is linked to higher levels of soluble adhesion molecules, including VCAM-1, ICAM-1, and E-selectin, in patients with obstructive coronary artery disease.

Area of Science:

  • Cardiovascular Research
  • Inflammation and Immunology
  • Biomarkers in Atherosclerosis

Background:

  • Endothelial cells and inflammatory cells are critical in coronary collateral development following arterial stenosis.
  • Soluble adhesion molecules (CAMs) mediate inflammatory cell interactions with the endothelium.

Purpose of the Study:

  • To compare serum levels of soluble CAMs between patients with poor versus well-developed coronary collaterals.
  • To investigate the association between coronary collateralization and levels of VCAM-1, ICAM-1, and E-selectin.

Main Methods:

  • Studied 97 non-diabetic patients with single-vessel coronary artery disease.
  • Assessed collateral supply using the Rentrop angiographic grading system (0-3).
  • Measured serum levels of VCAM-1, ICAM-1, and E-selectin via enzyme-linked immunosorbent assay.

Main Results:

  • Patients with poor collaterals (grades 0-1) had significantly higher levels of VCAM-1, ICAM-1, and E-selectin compared to those with good collaterals (grades 2-3).
  • A negative correlation was observed between collateral grade and soluble CAM levels, with grade 0 showing the highest and grade 3 the lowest molecule concentrations.
  • These findings were consistent across all measured adhesion molecules.

Conclusions:

  • Poor collateral circulation in obstructive coronary artery disease is associated with elevated serum levels of soluble CAMs.
  • Further research is warranted to clarify the precise role of these inflammatory markers in the context of inadequate collateral blood flow.
  • The study highlights a potential link between inflammation and impaired collateralization in coronary artery disease.
Abstract

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...