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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Human caliciviruses and pediatric gastroenteritis

Sarbelio Moreno-Espinosa1, Tibor Farkas, Xi Jiang

  • 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Seminars in Pediatric Infectious Diseases
|October 21, 2004
PubMed

Insights

Human caliciviruses, especially Noroviruses, are a leading cause of pediatric gastroenteritis, sometimes severe. Advances in diagnosis and vaccine development are ongoing for these difficult-to-culture viruses.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Molecular Diagnostics

Background:

  • Human caliciviruses, particularly Noroviruses, are a major cause of acute pediatric gastroenteritis, second only to rotavirus.
  • Noroviruses can cause severe illness requiring hospitalization, while Sapoviruses typically cause milder, endemic disease.
  • These viruses are genetically diverse, with multiple types circulating simultaneously.

Purpose of the Study:

  • To summarize recent advancements in understanding human caliciviruses.
  • To highlight the role of molecular diagnostics in surveillance.
  • To discuss progress in classification, diagnosis, and vaccine development.

Main Methods:

  • Molecular diagnostic methods for surveillance.
  • Genetic and antigenic characterization.
  • Research into Norovirus receptor recognition (histoblood group antigens).

Main Results:

  • Noroviruses identified as a primary cause of pediatric acute gastroenteritis.
  • Sapoviruses identified as a cause of milder endemic pediatric gastroenteritis.
  • Discovery of Norovirus binding to human histoblood group antigens.

Conclusions:

  • Human caliciviruses remain a significant public health concern in pediatrics.
  • Despite challenges in cultivation, substantial progress has been made.
  • Future developments in diagnosis and vaccines are anticipated.

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