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Updated: Aug 21, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Nesiritide: practical approach and benefits in the outpatient setting
Sharon Josephson1, Pamela P Barnett
1Heart Failure Treatment Program, Kaiser Permanente Mid-Atlantic States, Fairfax, VA 22033, USA. sharon.r.josephson@kp.org
Abstract:
Several trials have documented the efficacy of inpatient infusions of nesiritide in patients with heart failure. Early results from the Follow-Up Serial Infusions of Nesiritide (FUSION) study have supported the safety and efficacy of outpatient nesiritide infusions. Our Heart Failure Treatment Program began the use of outpatient nesiritide infusions to provide a cost-effective approach to improve quality of life in patients with advanced congestive heart failure not responding to standard therapy. We have provided outpatient nesiritide infusions for 2 years with favorable improvement in patient's quality of life and reduction in hospitalizations with no adverse outcomes demonstrated. Our experience utilizing nesiritide in the outpatient setting has been similar to the FUSION findings.
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